The Effects of Neuroplasticity on Major Depression Disorder in rTMS Combined with Antidepressant Treatments

Qinpu He


Many people suffer from major depression disorders (MMD) but antidepressant treatment doesn't work for 30% of MMD patients. The effects and therapeutic mechanism of repetitive transcranical magnetic stimulation (rTMS) are still unclear. This research studied the effects of treating MMD by rTMS by comparing a group of patients receiving both the antidepressant selective serotonin re-uptake (SSRI) and rTMS treatment with another group receiving. These results show that rTMS with antidepressant treatment can reduce MMD symptoms and therefore keep brain function in dynamic stability. The groups of patients receiving both rTMS treatments and antidepressant have an effective rate of 86.67% after 2 weeks and 72.00% after 10 weeks. The group of patients receiving just antidepressant treatment has an effective rate of 7.14% after 2 weeks and 54.76% after 10 weeks. This research found that rTMS with antidepressant treatment will result in a decrease in depression symptoms and the effective rates of rTMS with antidepressant treatment after 2 and 10 weeks were significantly higher than those of antidepressant treatment. This result suggests that antidepressant combined with rTMS treatment is more effective in treating MMD than just antidepressant treatment. Hence, rTMS can be more extensively used in the treatment of MMD patients.


Depression, rTMS, Treatment

Full Text: PDF


  • There are currently no refbacks.